Apba1^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Apba1^tm1Sud
• Name: amyloid beta precursor protein binding family A member 1; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:3697697
• Gene: Apba1 Location: Chr19:23736251-23926960 bp, + strand Genetic Position: Chr19, 18.45 cM
• Alliance: Apba1^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81845
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Flanking loxP sites were introduced to exon 1 and an frt-flanked neomycin resistance cassette was inserted into the downstream intron via homologous recombination. (J:81845)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apba1 Mutation: 32 strains or lines available

References

• Original: J:81845 Ho A, et al., A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1409-14
• All: 3 reference(s)