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Abcc4tm1Kruh
Targeted Allele Detail
Nomenclature
Symbol: Abcc4tm1Kruh
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 4; targeted mutation 1, Gary D Kruh
MGI ID: MGI:3697373
Synonyms: Mpr4-
Gene: Abcc4  Location: Chr14:118482692-118706219 bp, - strand  Genetic Position: Chr14, 62.24 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117326
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGenomic sequence encoding amino acids 77 to 101 was replaced with a neomycin resistance cassette. Absence of protein was confirmed in Western blot analysis. (J:117326)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcc4 Mutation:  111 strains or lines available
References
Original:  J:117326 Belinsky MG, et al., Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage. Cancer Res. 2007 Jan 1;67(1):262-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory