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Tg(BAT-lacZ)3Picc
Transgene Detail
Nomenclature
Symbol: Tg(BAT-lacZ)3Picc
Name: transgene insertion 3, Stefano Piccolo
MGI ID: MGI:3697064
Synonyms: Batgal, BAT-gal, BAT::gal, BATGAL, BATnlacZ
Transgene: Tg(BAT-lacZ)3Picc  Location: unknown  Genetic Position: Chr11, Syntenic
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F2
Transgene
description
Transgene Type:    Transgenic (Reporter)
Mutation:    Insertion
 
Mutation detailsMice with this transgene express nuclear beta-galactosidase under control of the beta-catenin-activated transgene (BAT) promoter. This promoter consists of a DNA fragment extending 0.13 kb upstream from the translation start site of the novel protein containing homeodomain (siamois) gene of Xenopus laevis, which contains the (beta-catenin non-responsive) minimal promoter of this natively beta-catenin activated gene, downstream of seven synthetic lymphoid enhancer factor/T-cell factor- (LEF/TCF-) binding sites that effectively restore the promoter's beta-catenin responsiveness. The transgene does not segregate randomly with respect to the Jup locus indicating that the transgene insertion site is genetically linked to Jup. (J:82727)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
This is one of three "BAT-gal" transgenic lines generated, which the authors state exhibitied "qualitatively identical expression patterns, although quantitative differences could be observed."
References
Original:  J:82727 Maretto S, et al., Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3299-304
All:  179 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory