About   Help   FAQ
Tg(Kdr-AGER)102Hyam
Transgene Detail
Summary
Symbol: Tg(Kdr-AGER)102Hyam
Name: transgene insertion 102, Hiroshi Yamamoto
MGI ID: MGI:3696984
Synonyms: RAGETg
Transgene: Tg(Kdr-AGER)102Hyam  Location: unknown  
Alliance: Tg(Kdr-AGER)102Hyam page
Transgene
origin
Strain of Origin:  (C57BL/6J x CBA/J)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Kdr-AGER)102Hyam expresses 1 gene
 
Mutation detailsThe mouse Kdr promoter (0.9 kb) and the 3.4 kb fragment containing the entire exonic and intronic region of the human AGER gene were ligated in the correct orientation and injected into fertilized oocytes. 6 founders were generated. Lines 102 and 103 had high expression and were used for further studies. (J:70495)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:70495 Yamamoto Y, et al., Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice. J Clin Invest. 2001 Jul;108(2):261-8
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory