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Crb1tm2Wij
Targeted Allele Detail
Nomenclature
Symbol: Crb1tm2Wij
Name: crumbs homolog 1 (Drosophila); targeted mutation 2, Jan Wijnholds
MGI ID: MGI:3696955
Synonyms: Crb1C249W
Gene: Crb1  Location: Chr1:139197056-139377100 bp, - strand  Genetic Position: Chr1, 60.87 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117415
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
    A point mutation in codon 249 resulted in a cysteine to tryptophan substitution in exon 3. (J:117415)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crb1 Mutation:  12 strains or lines available
References
Original:  J:117415 van de Pavert SA, et al., A single amino acid substitution (Cys249Trp) in Crb1 causes retinal degeneration and deregulates expression of pituitary tumor transforming gene Pttg1. J Neurosci. 2007 Jan 17;27(3):564-73
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory