Tg(ABCG5,ABCG8)63Ssf
Transgene Detail

Summary

• Symbol: Tg(ABCG5,ABCG8)63Ssf
• Name: transgene insertion 63, Silvia Santamarina-Fojo
• MGI ID: MGI:3696674
• Synonyms: G5/G8-Tg, hABCG5+G8-tg 63c
• Transgene: Tg(ABCG5,ABCG8)63Ssf Location: unknown
• Alliance: Tg(ABCG5,ABCG8)63Ssf page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ABCG5,ABCG8)63Ssf expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ABCG5 (64240)

  Abcg5

  (MGI:1351659)

  human

  ABCG8 (64241)

  Abcg8

  (MGI:1914720)

• Mutation details: The transgene is BAC clone 26313 (Incyte Genomics) containing the complete human ABCG5 and ABCG8 genes and flanking DNA. Approximately 63 copies of the BAC clone were inserted into the mouse genome. (J:90718)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:90718 Wu JE, et al., Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic mice. J Biol Chem. 2004 May 28;279(22):22913-25
• All: 1 reference(s)