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Glra1tm1Betz
Targeted Allele Detail
Nomenclature
Symbol: Glra1tm1Betz
Name: glycine receptor, alpha 1 subunit; targeted mutation 1, Heinrich Betz
MGI ID: MGI:3696673
Synonyms: Glra1(D80A)
Gene: Glra1  Location: Chr11:55514239-55608198 bp, - strand  Genetic Position: Chr11, 33.12 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117236
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
    The D80A substitution was inserted into exon 4. (J:117236)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Glra1 Mutation:  8 strains or lines available
References
Original:  J:117236 Hirzel K, et al., Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission. Neuron. 2006 Nov 22;52(4):679-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory