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Tg(Prnp-App/APPswe)E1-2Dbo
Transgene Detail
Nomenclature
Symbol: Tg(Prnp-App/APPswe)E1-2Dbo
Name: transgene insertion E1-2, David R Borchelt
MGI ID: MGI:3696473
Synonyms: E1-2 line, line E1-2, Mo/Hu APPswe, Mo/Hu APPswe line E1-2
Transgene: Tg(Prnp-App/APPswe)E1-2Dbo  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x C3H/HeJ)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp-App/APPswe)E1-2Dbo expresses 1 gene
 
Mutation detailsThis transgene expresses a modified mouse amyloid precursor protein cDNA encoding the 695-amino acid isoform with a "humanized" Abeta domain amino acid sequence that includes the familial Alzheimer disease- (FAD-) associated Swedish double mutation (Lys595Asn and Met596Leu). The cDNA was inserted into an expression cassette containing the promoter, 5' intronic and 3' untranslated region sequences of the mouse prion protein gene. (J:80782)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Three transgenic lines were generated and designated by the authors lines Q2-2, E1-2 and C3-3 (Tg(APP695)3Dbo). They were estimated, on the basis of Southern blot analysis, to carry 3-10 copies of the transgene.

References
Original:  J:80782 Borchelt DR, et al., A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genet Anal. 1996 Dec;13(6):159-63
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory