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Brca1tm1Brn
Targeted Allele Detail
Summary
Symbol: Brca1tm1Brn
Name: breast cancer 1, early onset; targeted mutation 1, Anton Berns
MGI ID: MGI:3696057
Synonyms: Brca1F, Brca1F5-13, Brca1loxP, Brca1tm2Brn
Gene: Brca1  Location: Chr11:101379590-101442781 bp, - strand  Genetic Position: Chr11, 65.18 cM, cytoband D
Alliance: Brca1tm1Brn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117113
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were introduced into introns 3 and 13 to flox exons 5 through 13. A neo cassette, inserted as a selectable marker, was removed following a cross to a cre deletor strain (Tg(CMV-cre)1Cgn mice). Southern blot analysis was used to confirm genomic modifications. (J:126551)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Brca1tm1Brn
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Brca1 Mutation:  113 strains or lines available
References
Original:  J:117113 Clark-Knowles KV, et al., Conditional inactivation of Brca1 in the mouse ovarian surface epithelium results in an increase in preneoplastic changes. Exp Cell Res. 2007 Jan 1;313(1):133-45
All:  45 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory