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Targeted Allele Detail
Symbol: Brca1tm1Brn
Name: breast cancer 1, early onset; targeted mutation 1, Anton Berns
MGI ID: MGI:3696057
Synonyms: Brca1F, Brca1F5-13, Brca1loxP, Brca1tm2Brn
Gene: Brca1  Location: Chr11:101488764-101551955 bp, - strand  Genetic Position: Chr11, 65.18 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:117113
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsLoxP sites were introduced into introns 3 and 13 to flox exons 5 through 13. A neo cassette, inserted as a selectable marker, was removed following a cross to a cre deletor strain (Tg(CMV-cre)1Cgn mice). Southern blot analysis was used to confirm genomic modifications. (J:126551)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Brca1 Mutation:  75 strains or lines available
Original:  J:117113 Clark-Knowles KV, et al., Conditional inactivation of Brca1 in the mouse ovarian surface epithelium results in an increase in preneoplastic changes. Exp Cell Res. 2007 Jan 1;313(1):133-45
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory