Tg(Pbsn-TP53*R273H)1Elga
Transgene Detail

Summary

• Symbol: Tg(Pbsn-TP53*R273H)1Elga
• Name: transgene insertion 1, Ada Elgavish
• MGI ID: MGI:3695907
• Transgene: Tg(Pbsn-TP53*R273H)1Elga Location: unknown
• Alliance: Tg(Pbsn-TP53*R273H)1Elga page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pbsn-TP53*R273H)1Elga expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TP53 (7157)

  Trp53

  (MGI:98834)

  Transgene codes for a protein with an arginine to histidine mutation.

• Mutation details: A transgenic construct was made that consisted of the rat probasin promoter driving the expression of a human TP53 cDNA that had a mutation in codon 273 resulting in an arginine to histidine substitution in the encoded protein. Immunohistochemical analysis of dorsolateral prostate sections confirmed the expression of the mutant protein. (J:92122)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:92122 Elgavish A, et al., Transgenic mouse with human mutant p53 expression in the prostate epithelium. Prostate. 2004 Sep 15;61(1):26-34
• All: 1 reference(s)