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Tg(Syn1-ADCY7)11004Btab
Transgene Detail
Nomenclature
Symbol: Tg(Syn1-ADCY7)11004Btab
Name: transgene insertion 11004, Boris Tabakoff
MGI ID: MGI:3695128
Synonyms: Adcy7huTG
Transgene: Tg(Syn1-ADCY7)11004Btab  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Syn1-ADCY7)11004Btab expresses 1 gene
 
Mutation detailsThis transgene consists of a 4.5 kb fragment of the rat synapsin I promotor, a 3.6 kb fragment of human ADCY7 cDNA, and a 650 bp fragment of the human growth hormone gene. Expression is confined to the central nervous system. Three lines (11004, 11012, and 10115) with high levels of expression were created which all have identical phenotype. One of these lines (10115) was generated using FVB/N oocytes while the other 2 used hybrid C57BL/6 x SJL oocytes. This is a representative record for all three lines (J:116797)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:116797 Yoshimura M, et al., Overexpression of type 7 adenylyl cyclase in the mouse brain enhances acute and chronic actions of morphine. Mol Pharmacol. 2000 Nov;58(5):1011-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory