Pparg^tm1Avp
Targeted Allele Detail

Summary

• Symbol: Pparg^tm1Avp
• Name: peroxisome proliferator activated receptor gamma; targeted mutation 1, Antonio Vidal-Puig
• MGI ID: MGI:3694813
• Synonyms: PPARgammaP465L
• Gene: Pparg Location: Chr6:115337912-115467360 bp, + strand Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
• Alliance: Pparg^tm1Avp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116568
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Single point mutation
• A C to T transition resulting in the P465L mutation was inserted into exon 6. (J:116568)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pparg Mutation: 39 strains or lines available

References

• Original: J:116568 Gray SL, et al., Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice. Diabetes. 2006 Oct;55(10):2669-77
• All: 6 reference(s)