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Lyl1tm1Fsky
Targeted Allele Detail
Nomenclature
Symbol: Lyl1tm1Fsky
Name: lymphoblastomic leukemia 1; targeted mutation 1, Fred Sablitzky
MGI ID: MGI:3693950
Synonyms: Lyl-1-, Lyl-1LacZ, Lyl1tm1Vchr
Gene: Lyl1  Location: Chr8:84701423-84704716 bp, + strand  Genetic Position: Chr8, 41.02 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:116300
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ-neo cassette was inserted in frame into exon 4, deleting the entire 3' end including sequences encoding the HLH domain. (J:116300)
Schematic comparison of the two targeted Lyl1tm1Mago and Lyl1tm1Fsky alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 5 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lyl1 Mutation:  5 strains or lines available
References
Original:  J:116300 Capron C, et al., The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation. Blood. 2006 Jun 15;107(12):4678-86
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory