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Transgene Detail
Symbol: Tg(tetO-COX8A/EYFP)1Ksn
Name: transgene insertion 1, Tibor Kristian
MGI ID: MGI:3693934
Synonyms: pTRE2-mito/eYFP, Tg(tetO-EYFP-Mito)1Ksn, TRE-mito/EYFP
Transgene: Tg(tetO-COX8A/EYFP)1Ksn  Location: unknown  
Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Mutation detailsA construct encoding a fusion protein comprising the mitochondrial targeting sequence from human cytochrome c oxidase subunit 8A (ubiquitous) joined to enhanced yellow fluorescent protein (EYFP) was placed downstream of the tetracycline responsive element (tetO) and upsteam of a beta-globin polyadenylation signal. A mouse with this transgene can be bred with another transgenic mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA) under control of a selected promoter to produce bitransgenic mice in which mitochondrial EYFP expression can be regulated in a tissue-specific manner by administration/removal of the tetracycline analog, doxycycline. (J:118452)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:118452 Chandrasekaran K, et al., Neuron-specific conditional expression of a mitochondrially targeted fluorescent protein in mice. J Neurosci. 2006 Dec 20;26(51):13123-7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory