Fn3k^tm1Mvdc
Targeted Allele Detail

Summary

• Symbol: Fn3k^tm1Mvdc
• Name: fructosamine 3 kinase; targeted mutation 1, Maria Veiga-Da-Cunha
• MGI ID: MGI:3693634
• Synonyms: Fn3k^-
• Gene: Fn3k Location: Chr11:121325779-121341316 bp, + strand Genetic Position: Chr11, 85.38 cM, cytoband E2
• Alliance: Fn3k^tm1Mvdc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116037
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace part of exon 1 and all of exon 2 with a beta-gal and neomycin resistance cassette. Erythrocytes, kidney and brain samples from mutants confirmed absence of transcript. Beta-gal expression was not detected in mutants. (J:116037)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fn3k Mutation: 13 strains or lines available

References

• Original: J:116037 Veiga da-Cunha M, et al., Increased protein glycation in fructosamine 3-kinase-deficient mice. Biochem J. 2006 Oct 15;399(2):257-64
• All: 2 reference(s)