Six3^tm2Gco
Targeted Allele Detail

Summary

• Symbol: Six3^tm2Gco
• Name: sine oculis-related homeobox 3; targeted mutation 2, Guillermo Oliver
• MGI ID: MGI:3693321
• Synonyms: Six3^f, Six3^flox
• Gene: Six3 Location: Chr17:85921036-85933619 bp, + strand Genetic Position: Chr17, 55.42 cM
• Alliance: Six3^tm2Gco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116102
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted to flank exon 1, which encodes the Six domain and homeodomain. (J:116102)

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Six3 Mutation: 13 strains or lines available

References

• Original: J:116102 Liu W, et al., Six3 activation of Pax6 expression is essential for mammalian lens induction and specification. EMBO J. 2006 Nov 15;25(22):5383-95
• All: 16 reference(s)