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Tg(tetO/CMV-KRAS*G12C)9.1Msmi
Transgene Detail
Summary
Symbol: Tg(tetO/CMV-KRAS*G12C)9.1Msmi
Name: transgene insertion 9.1, Mark Miller
MGI ID: MGI:3693226
Synonyms: Ki-rasG12C
Transgene: Tg(tetO/CMV-KRAS*G12C)9.1Msmi  Location: unknown  
Alliance: Tg(tetO/CMV-KRAS*G12C)9.1Msmi page
Transgene
origin
Strain of Origin:  FVB/NTac
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Tg(tetO/CMV-KRAS*G12C)9.1Msmi expresses 1 gene
 
Mutation detailsA genomic segment including the KRASG12C mutation was cloned from the H358 human lung bronchioalveolar cell line and placed under the regulation of a tetracycline-inducible (tetO)/cytomegalovirus (CMV) promoter. Copy number is estimated at 22. (J:102839)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Tumor Data
List all tumor models in MMHCdb carrying Tg(tetO/CMV-KRAS*G12C)9.1Msmi
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:102839 Floyd HS, et al., Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model. Carcinogenesis. 2005 Dec;26(12):2196-206
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory