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Targeted Allele Detail
Symbol: Boctm1Aok
Name: biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein; targeted mutation 1, Ami Okada
MGI ID: MGI:3692939
Synonyms: Boc-
Gene: Boc  Location: Chr16:44485045-44558870 bp, - strand  Genetic Position: Chr16, 28.81 cM, cytoband B5
Germline Transmission:  Earliest citation of germline transmission: J:115577
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsHomologous recombination was used to insert a gene trap vector encoding a strong splice acceptor site, transmembrane domain and beta-geo followed by an IRES-PLAP upstream of the exon encoding the transmembrane domain. The allele proved to be severely hypomorphic. (J:115577)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Boc Mutation:  42 strains or lines available
Original:  J:115577 Okada A, et al., Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature. 2006 Nov 16;444(7117):369-73
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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