Stx2^repro34
Chemically induced Allele Detail

Summary

• Symbol: Stx2^repro34
• Name: syntaxin 2; reproductive mutation 34, JAX Reproductive Mutagenesis Program
• MGI ID: MGI:3692880
• Synonyms: G1-536-1
• Gene: Stx2 Location: Chr5:129061621-129085638 bp, - strand Genetic Position: Chr5, 67.99 cM
• Alliance: Stx2^repro34 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A C-to-T transition mutation at nucleotide 273 of the cDNA causes a nonsense mutation, resulting in premature termination at codon 41 of the gene. (J:136575)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stx2 Mutation: 24 strains or lines available

Notes

In vitro clinic: Very low testis weight, low seminal vesicle weight, no epididymal sperm recovered. Histology evaluation: Abnormal spermiogenesis with accumulation of meiotic division-phase spermatocytes and degenerating round spermatids present in multinucleated cell bodies.

References

• Original: J:92463 JAX Reproductive Mutagenesis Program, Heritable mouse mutants from The Jackson Laboratory Reproductive Genomics Mutagenesis Program. MGI Direct Data Submission. 2004-7
• All: 5 reference(s)