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Targeted Allele Detail
Symbol: Tnftm3Gkl
Name: tumor necrosis factor; targeted mutation 3, George Kollias
MGI ID: MGI:3692522
Synonyms: TNFdelta1-12, Tnftm
Gene: Tnf  Location: Chr17:35199381-35202007 bp, - strand  Genetic Position: Chr17, 18.59 cM
Germline Transmission:  Earliest citation of germline transmission: J:114740
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 724 bp sequence containing the second and third exons was replaced with a mutated 511 bp fragment carrying a deletion of the first twelve amino acids of soluble TNF. The neo was subsequently removed. (J:114740)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnf Mutation:  35 strains or lines available
Original:  J:114740 Alexopoulou L, et al., Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity. Eur J Immunol. 2006 Oct;36(10):2768-80
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory