About   Help   FAQ
Acadmtm1Uab
Targeted Allele Detail
Nomenclature
Symbol: Acadmtm1Uab
Name: acyl-Coenzyme A dehydrogenase, medium chain; targeted mutation 1, University of Alabama
MGI ID: MGI:3692446
Synonyms: MCAD-
Gene: Acadm  Location: Chr3:153922357-153944632 bp, - strand  Genetic Position: Chr3, 78.77 cM
Histopathology of wild-type and Acadmtm1Uab/Acadmtm1Uab mice.

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:115759
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed duplicate exons 8-10. Translation of the duplicated exon 8 resullted in the formation of a premature stop codon and therefore the resulting protein lacks the C-terminal domain alpha-helixes. (J:115759)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Acadm Mutation:  24 strains or lines available
References
Original:  J:115759 Tolwani RJ, et al., Medium-chain acyl-CoA dehydrogenase deficiency in gene-targeted mice. PLoS Genet. 2005 Aug;1(2):e23
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/12/2018
MGI 6.12
The Jackson Laboratory