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Bbc3tm1Gpz
Targeted Allele Detail
Nomenclature
Symbol: Bbc3tm1Gpz
Name: BCL2 binding component 3; targeted mutation 1, Gerard P Zambetti
MGI ID: MGI:3692386
Synonyms: Puma-
Gene: Bbc3  Location: Chr7:16308393-16318205 bp, + strand  Genetic Position: Chr7, 8.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:115660
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1-3, which contain the transcription and translation start sites and the entire BH3 domain were replaced by a neo. Western blot and real-time PCR confirmed absence of expression in hematopoietic cells. (J:115660)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bbc3 Mutation:  14 strains or lines available
References
Original:  J:115660 Jeffers JR, et al., Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell. 2003 Oct;4(4):321-8
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory