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Pik3catm1.1Jjz
Targeted Allele Detail
Nomenclature
Symbol: Pik3catm1.1Jjz
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 1.1, Jean J Zhao
MGI ID: MGI:3691485
Synonyms: p110a -
Gene: Pik3ca  Location: Chr3:32397671-32466107 bp, + strand  Genetic Position: Chr3, 15.7 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:115274
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 1 was removed via transient expression of cre recombinase. Absence of the full length or any truncated form of the p110a isoform was confirmed by Western blot of MEFs. (J:115274)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3ca Mutation:  33 strains or lines available
References
Original:  J:115274 Zhao JJ, et al., The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16296-300
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/23/2017
MGI 6.09
The Jackson Laboratory