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Polhtm2Fmh
Targeted Allele Detail
Nomenclature
Symbol: Polhtm2Fmh
Name: polymerase (DNA directed), eta (RAD 30 related); targeted mutation 2, Fumio Hanaoka
MGI ID: MGI:3691063
Synonyms: Polh-, Polh3Han, Polhtm3Han
Gene: Polh  Location: Chr17:46172004-46202625 bp, - strand  Genetic Position: Chr17, 22.9 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:115000
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A targeting vector was inserted into exon 8, resulting in the production of a truncated protein. (J:115000)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Polh Mutation:  14 strains or lines available
References
Original:  J:115000 Ohkumo T, et al., UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota. Mol Cell Biol. 2006 Oct;26(20):7696-706
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory