Tg(KRT5-Lep)1Flar
Transgene Detail

Summary

• Symbol: Tg(KRT5-Lep)1Flar
• Name: transgene insertion 1, Fernando Larcher
• MGI ID: MGI:3690983
• Transgene: Tg(KRT5-Lep)1Flar Location: unknown
• Alliance: Tg(KRT5-Lep)1Flar page

Transgene origin

• Strain of Origin: (C57BL/6J X DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT5-Lep)1Flar expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Lep (MGI:104663)

• Tg(KRT5-Lep)1Flar expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cattle	KRT5 (281268)

• Mutation details: The mouse Leptin gene was placed under the control of the bovine KRT5 promoter. Two lines were created. L1 contains about 20 transgene copies and L2 contains about 30 copies. (J:115148, J:129819)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:115148 Larcher F, et al., A cutaneous gene therapy approach to human leptin deficiencies: correction of the murine ob/ob phenotype using leptin-targeted keratinocyte grafts. FASEB J. 2001 Jul;15(9):1529-38
• All: 3 reference(s)