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Tg(Itgax-cre/ERT)61Gkl
Transgene Detail
Summary
Symbol: Tg(Itgax-cre/ERT)61Gkl
Name: transgene insertion 61, George Kollias
MGI ID: MGI:3690924
Synonyms: CD11cCreERT, Tg(CD11c-CreERt)61Gkl, Tg(Itgax-cre/ESR1)61Gkl
Transgene: Tg(Itgax-cre/ERT)61Gkl  Location: unknown  
Alliance: Tg(Itgax-cre/ERT)61Gkl page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Itgax-cre/ERT)61Gkl expression driven by 1 gene
 
Mutation detailsThe protein product of this transgene, whose transcription is under control of the dendritic cell- (DC-) specific mouse integrin alpha X (Itgax/Cdc11c) promoter, is a fusion of Cre recombinase and a mutant hormone-binding domain from human estrogen receptor 1 (ESR1). Following TAM treatment of mice bearing both this transgene and an EGFP-expressing Cre recombinase reporter transgene, green fluorescence was observed in 4-8% of CD11c+ cells in the spleen, lymph nodes, and thymus, but in no CD11c- cells. Staining of Cdc11c+ splenocytes from these mice with CD8alpha-APC/CD-PE 40 hours after TAM administration revealed fluorescence of all major classes of DC. (J:114742)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Itgax (mouse)
Summary of all recombinase alleles driven by Itgax.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:114742 Probst HC, et al., Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance. Immunity. 2003 May;18(5):713-20
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory