Fas^tm1Cgn
Targeted Allele Detail

Summary

• Symbol: Fas^tm1Cgn
• Name: Fas cell surface death receptor; targeted mutation 1, University of Cologne
• MGI ID: MGI:3690464
• Synonyms: fas^fl
• Gene: Fas Location: Chr19:34268066-34305172 bp, + strand Genetic Position: Chr19, 29.48 cM
• Alliance: Fas^tm1Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114948
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 9, the death domain encoding exon, was flanked by loxP sites via homologous recombination. (J:114948)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fas Mutation: 82 strains or lines available

References

• Original: J:114948 Hao Z, et al., T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J Exp Med. 2004 May 17;199(10):1355-65
• All: 23 reference(s)