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Fastm1Cgn
Targeted Allele Detail
Nomenclature
Symbol: Fastm1Cgn
Name: Fas (TNF receptor superfamily member 6); targeted mutation 1, University of Cologne
MGI ID: MGI:3690464
Synonyms: fasfl
Gene: Fas  Location: Chr19:34290666-34327772 bp, + strand  Genetic Position: Chr19, 29.48 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:114948
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    Exon 9, the death domain encoding exon, was flanked by loxP sites via homologous recombination. (J:114948)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fas Mutation:  47 strains or lines available
References
Original:  J:114948 Hao Z, et al., T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J Exp Med. 2004 May 17;199(10):1355-65
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory