Rb1cc1tm1.2Guan
Targeted Allele Detail
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Symbol: |
Rb1cc1tm1.2Guan |
Name: |
RB1-inducible coiled-coil 1; targeted mutation 1.2, Jun-Lin Guan |
MGI ID: |
MGI:3690328 |
Synonyms: |
Fip200delta |
Gene: |
Rb1cc1 Location: Chr1:6284858-6346599 bp, + strand Genetic Position: Chr1, 1.89 cM, cytoband A2
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Alliance: |
Rb1cc1tm1.2Guan page
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Defective heart and liver development in Rb1cc1tm1.2Guan/Rb1cc1tm1.2Guan embryos
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:114498
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Parent Cell Line: |
E14.1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: Cre mediated excision resulted in the loss of exons 4 and 5 and the neo. The deletion led to a frame shift due to direct splicing of exon 3 to exon 6, producing a truncated, nonfunctional peptide.
(J:114498)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rb1cc1 Mutation: |
82 strains or lines available
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Original: |
J:114498 Gan B, et al., Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. J Cell Biol. 2006 Oct 9;175(1):121-33 |
All: |
6 reference(s) |
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