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Myh6tm1Ces
Targeted Allele Detail
Nomenclature
Symbol: Myh6tm1Ces
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha; targeted mutation 1, Christine E Seidman
MGI ID: MGI:3690299
Synonyms: MHCF764L
Gene: Myh6  Location: Chr14:54941921-54966927 bp, - strand  Genetic Position: Chr14, 28.01 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:114549
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
    The F764L mutation was inserted into exon 21. (J:114549)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myh6 Mutation:  28 strains or lines available
References
Original:  J:114549 Schmitt JP, et al., Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14525-30
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory