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Dtx1tm1Mjb
Targeted Allele Detail
Nomenclature
Symbol: Dtx1tm1Mjb
Name: deltex 1, E3 ubiquitin ligase; targeted mutation 1, Michael J Bevan
MGI ID: MGI:3690124
Synonyms: Dx1-KO
Gene: Dtx1  Location: Chr5:120680202-120711927 bp, - strand  Genetic Position: Chr5, 60.64 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:114658
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe ATG and the first 87 amino acids were removed via cre mediated recombination. This sequence included the first WWE repeat. Absence of protein was confirmed by Western blot analysis of thymocytes. (J:114658)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dtx1 Mutation:  22 strains or lines available
References
Original:  J:114658 Lehar SM, et al., T cells develop normally in the absence of both Deltex1 and Deltex2. Mol Cell Biol. 2006 Oct;26(20):7358-71
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory