Scn10a^{tm3(cre/ERT2)Jwo}
Targeted Allele Detail

Summary

• Symbol: Scn10a^{tm3(cre/ERT2)Jwo}
• Name: sodium channel, voltage-gated, type X, alpha; targeted mutation 3, John N Wood
• MGI ID: MGI:3689893
• Synonyms: Nav1.8-CreERT2, Scn10a^{tm3(cre/ERT2)Jnw}
• Gene: Scn10a Location: Chr9:119437522-119548388 bp, - strand Genetic Position: Chr9, 71.33 cM, cytoband distal
• Alliance: Scn10a^{tm3(cre/ERT2)Jwo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114488
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Scn10a^{tm3(cre/ERT2)Jwo} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Scn10a (MGI:108029)

• Mutation details: Cre recombinaseERT2 cDNA, 3' UTR of Scn10a, and an FRT flanked neo were knocked into the initiator methionine so that Cre replaced the ATG. Crossing with mice expressing Flp recombinase in the germ line excised the floxed neo. (J:114488)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Scn10a (mouse) Summary of all recombinase alleles driven by Scn10a. Comparative matrix view of recombinase activities Alliance mouse Scn10a gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Scn10a Mutation: 102 strains or lines available

References

• Original: J:114488 Zhao J, et al., Tamoxifen-inducible NaV1.8-CreERT2 recombinase activity in nociceptive neurons of dorsal root ganglia. Genesis. 2006 Aug;44(8):364-71
• All: 1 reference(s)