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Targeted Allele Detail
Symbol: Il5tm3Anjm
Name: interleukin 5; targeted mutation 3, Andrew NJ McKenzie
MGI ID: MGI:3689810
Synonyms: il5-, Il-5KO
Gene: Il5  Location: Chr11:53720794-53725103 bp, + strand  Genetic Position: Chr11, 31.99 cM, cytoband A5/B1
Germline Transmission:  Earliest citation of germline transmission: J:113543
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA replacement vector was used to insert a cassette containing: an SpeI linker with stop codons in all three reading frames, a retroviral internal ribosomal entry site (IRES) element fused to the lacZ reporter gene with a 3' polyA signal, and the hygromycin gene into a site in exon 3 of the Il5 gene. (J:113543)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il5 Mutation:  24 strains or lines available
Original:  J:113543 Fallon PG, et al., IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13. Immunity. 2002 Jul;17(1):7-17
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory