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Slc6a3tm1.1(cre)Bkmn
Targeted Allele Detail
Nomenclature
Symbol: Slc6a3tm1.1(cre)Bkmn
Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1.1, Cristina M Backman
MGI ID: MGI:3689434
Synonyms: DATCre, DatIREScre, DatIRESCre, DAT-IRES-Cre
Gene: Slc6a3  Location: Chr13:73536747-73578672 bp, + strand  Genetic Position: Chr13, 40.1 cM
Altered dopamine neurons in the ventral midbrain of Ptentm1Hwu/Ptentm1Hwu Slc6a3tm1.1(cre)Bkmn/Slc6a3+ mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:114466
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neo was removed from the locus, leaving cre recombinase cDNA in the 3' UTR to allow bicistronic mRNA expression. (J:114466)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Slc6a3     Summary of all recombinase alleles driven by Slc6a3. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 18 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc6a3 Mutation:  50 strains or lines available
Notes
The targeting vector was electroporated into both R1 and C57BL/6 ES cells.
References
Original:  J:114466 Backman CM, et al., Characterization of a mouse strain expressing Cre recombinase from the 3' untranslated region of the dopamine transporter locus. Genesis. 2006 Aug;44(8):383-90
All:  120 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory