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Targeted Allele Detail
Symbol: Apctm2Rak
Name: APC, WNT signaling pathway regulator; targeted mutation 2, Raju Kucherlapati
MGI ID: MGI:3688435
Synonyms: Apc580S, ApcCKO, Apcloxp
Gene: Apc  Location: Chr18:34220924-34322552 bp, + strand  Genetic Position: Chr18, 18.53 cM
Stunted growth, short whiskers, sparse hair coat and abnormal tooth development in the Apctm2Rak/Apctm2Rak Tg(KRT14-cre)8Brn/0 mouse

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:114152
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsLoxP sites were inserted through homologous recombination to flank exon 14. An adjacently inserted frt-flanked neomycin selection cassette was removed through Flp-mediated recombination, leaving a single frt site in intron 14. (J:114152)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 22 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apc Mutation:  59 strains or lines available
Original:  J:114152 Kuraguchi M, et al., Adenomatous Polyposis Coli (APC) is required for normal development of skin and thymus. PLoS Genet. 2006;2(9):e146
All:  39 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory