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Tg(Tcra2B4)1Mmd
Transgene Detail
Nomenclature
Symbol: Tg(Tcra2B4)1Mmd
Name: transgene insertion 1, Mark M Davis
MGI ID: MGI:3688270
Synonyms: 2B4alpha Tg, 2B4alphEH
Transgene: Tg(Tcra2B4)1Mmd  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x C3H/HeJ)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Tcra2B4)1Mmd expresses 1 gene
 
Mutation detailsA 2.3 kb fragment of the Valpha gene, containing 2 kb of 5' flanking sequence was fused to a 195 bp cDNA fragment covering the unique V-J junction, with the remaining nucleotides of the Jalpha region plus ~100 bp of JC intron sequence. This VJ segment was inserted upstream of a 9.8 kb Calpha clone containing all the Calpha exons and extending .5 kb downstream of the polyA signal. A 683-bp fragment containing the immunoglobulin heavy-chain enhancer (EH) was inserted at the junction between the VJ and Calpha segments. (J:69570)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:69570 Berg LJ, et al., Expression of T-cell receptor alpha-chain genes in transgenic mice. Mol Cell Biol. 1988 Dec;8(12):5459-69
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/10/2019
MGI 6.14
The Jackson Laboratory