Slc16a2^tm1Sref
Targeted Allele Detail

Summary

• Symbol: Slc16a2^tm1Sref
• Name: solute carrier family 16 (monocarboxylic acid transporters), member 2; targeted mutation 1, Samuel Refetoff
• MGI ID: MGI:3687949
• Synonyms: Mct8^2LoxP
• Gene: Slc16a2 Location: ChrX:102741020-102865589 bp, - strand Genetic Position: ChrX, 46.29 cM
• Alliance: Slc16a2^tm1Sref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113732
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A vector containing a neo and tACE Cre recombinase flanked by loxP sites was inserted into intron 2 and a third loxP site was inserted into intron 3. The cre cassette excises itself upon passage through the germline, leaving exon 3 floxed. (J:113732)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc16a2 Mutation: 13 strains or lines available

References

• Original: J:113732 Dumitrescu AM, et al., Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice. Endocrinology. 2006 Sep;147(9):4036-43
• All: 2 reference(s)