Nlgn3^tm1Bros
Targeted Allele Detail

Summary

• Symbol: Nlgn3^tm1Bros
• Name: neuroligin 3; targeted mutation 1, Nils Brose
• MGI ID: MGI:3687640
• Gene: Nlgn3 Location: ChrX:100342785-100364956 bp, + strand Genetic Position: ChrX, 43.95 cM
• Alliance: Nlgn3^tm1Bros page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113647
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo was inserted into the locus to replace the exon encompassing the translational start site at 574 bp. Western blot confirmed absence of full length and truncated protein in these mutants. (J:113647)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlgn3 Mutation: 35 strains or lines available

References

• Original: J:113647 Varoqueaux F, et al., Neuroligins determine synapse maturation and function. Neuron. 2006 Sep 21;51(6):741-54
• All: 9 reference(s)