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Nfkbibtm1Jpmz
Targeted Allele Detail
Nomenclature
Symbol: Nfkbibtm1Jpmz
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta; targeted mutation 1, Joseph P Mizgerd
MGI ID: MGI:3687303
Gene: Nfkbib  Location: Chr7:28758251-28767512 bp, - strand  Genetic Position: Chr7, 16.91 cM, cytoband A3-B3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:113618
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA sequence including nucleotides 253-987, over 60% of the coding region including the ankyrin repeats, was deleted from the locus. Western blot confirmed the absence of protein in lungs from mutant mice. (J:113618)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfkbib Mutation:  5 strains or lines available
References
Original:  J:113618 Mizgerd JP, et al., Functions of IkappaB proteins in inflammatory responses to Escherichia coli LPS in mouse lungs. Am J Respir Cell Mol Biol. 2002 Nov;27(5):575-82
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory