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Tnfrsf1atm2Gkl
Targeted Allele Detail
Nomenclature
Symbol: Tnfrsf1atm2Gkl
Name: tumor necrosis factor receptor superfamily, member 1a; targeted mutation 2, George Kollias
MGI ID: MGI:3686874
Synonyms: p55TnfRcneo, TnfRIflxneo
Gene: Tnfrsf1a  Location: Chr6:125349723-125362483 bp, + strand  Genetic Position: Chr6, 59.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:113314
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA floxed neo was inserted into intron 5 of the locus to create this conditional gain-of-function allele. The presence of the neo prevents expression of the gene. (J:113314)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfrsf1a Mutation:  26 strains or lines available
References
Original:  J:113314 Victoratos P, et al., FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses. Immunity. 2006 Jan;24(1):65-77
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory