Neo1^{Gt(KST265)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Neo1^{Gt(KST265)Byg}
• Name: neogenin; gene trap KST265, BayGenomics
• MGI ID: MGI:3665445
• Synonyms: Neo1^-, Neo1^Gt, neogenin^m
• Gene: Neo1 Location: Chr9:58781970-58943724 bp, - strand Genetic Position: Chr9, 31.81 cM
• Alliance: Neo1^{Gt(KST265)Byg} page

Mutation origin

• Mutant Cell Line: KST265
• Germline Transmission: Earliest citation of germline transmission: J:109023
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Hypomorph, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1TMpf
• Mutation details: A beta-geo/PLAP secretory gene trap vector (pGT1TMpfs) was inserted into intron 19. The insertion site was mapped to nucleotide 58,780,672 of chr 9 (build GRCm37). The insertion was accompanied by a deletion of 922 bp and an inversion of a 923 bp sequence immediately adjacent to the insertion (inverting bp 58,780,672-58,779,784). (J:67920, J:109043, J:164943)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  KST265	CC144717 ; (MGI Seq Detail)	5' RACE	Chr9:58863241-58886045 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  13 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	54 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Neo1 Mutation: 63 strains or lines available

References

• Original: J:109023 Srinivasan K, et al., Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis. Dev Cell. 2003 Mar;4(3):371-82
• All: 24 reference(s)