Tg(Col2a1-cre/ERT)KA3Smac
Transgene Detail

Summary

• Symbol: Tg(Col2a1-cre/ERT)KA3Smac
• Name: transgene insertion KA3, Susan Mackem
• MGI ID: MGI:3665440
• Synonyms: Col2CreER^T, Tg(Col2a1-cre/ESR1)1Smac, Tg(Col2a1-cre/ESR1)KA3Smac
• Transgene: Tg(Col2a1-cre/ERT)KA3Smac Location: unknown
• Alliance: Tg(Col2a1-cre/ERT)KA3Smac page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Col2a1-cre/ERT)KA3Smac expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Col2a1

• Mutation details: This transgene expresses a tamoxifen-inducible form of cre recombinase driven by the Col2a1 promoter in cartilage. The cre recombinase coding region is joined to a sequence encoding the ligand-binding domain of the human estrogen receptor with glycine to arginine missense mutation at position 521. This substitution enables the domain to bind to tamoxifen while ablating the estradiol binding ability. (J:111627)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Col2a1 (species not specified) Summary of all recombinase alleles driven by Col2a1. Comparative matrix view of recombinase activities

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:111627 Nakamura E, et al., Kinetics of tamoxifen-regulated Cre activity in mice using a cartilage-specific CreER(T) to assay temporal activity windows along the proximodistal limb skeleton. Dev Dyn. 2006 Aug 7;235(9):2603-2612
• All: 75 reference(s)