Ncam1^tm1Klc
Targeted Allele Detail

Summary

• Symbol: Ncam1^tm1Klc
• Name: neural cell adhesion molecule 1; targeted mutation 1, Kathryn L Crossin
• MGI ID: MGI:3665409
• Gene: Ncam1 Location: Chr9:49413436-49710225 bp, - strand Genetic Position: Chr9, 26.83 cM
• Alliance: Ncam1^tm1Klc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46176
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A beta-gal was inserted between the transcription and translation initiation sites, placing the lacZ under control of the endogenous promoter. Northern blot confirmed absence of transcript in mutant brain samples. Absence of protein was confirmed by Western blot analysis. (J:46176)

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncam1 Mutation: 65 strains or lines available

References

• Original: J:46176 Holst BD, et al., Allosteric modulation of AMPA-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, N-CAM. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2597-602
• All: 2 reference(s)