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Ncam1tm1Klc
Targeted Allele Detail
Nomenclature
Symbol: Ncam1tm1Klc
Name: neural cell adhesion molecule 1; targeted mutation 1, Kathryn L Crossin
MGI ID: MGI:3665409
Gene: Ncam1  Location: Chr9:49502136-49798925 bp, - strand  Genetic Position: Chr9, 26.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46176
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA beta-gal was inserted between the transcription and translation initiation sites, placing the lacZ under control of the endogenous promoter. Northern blot confirmed absence of transcript in mutant brain samples. Absence of protein was confirmed by Western blot analysis. (J:46176)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 20 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncam1 Mutation:  41 strains or lines available
References
Original:  J:46176 Holst BD, et al., Allosteric modulation of AMPA-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, N-CAM. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2597-602
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory