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Targeted Allele Detail
Symbol: Thtm1Gfng
Name: tyrosine hydroxylase; targeted mutation 1, Guoping Feng
MGI ID: MGI:3665325
Synonyms: THYFP
Gene: Th  Location: Chr7:142892779-142899995 bp, - strand  Genetic Position: Chr7, 88.06 cM
Germline Transmission:  Earliest citation of germline transmission: J:113138
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to replace exon 1, intron 1 and the first 15 bp of exon 2 with cDNA encoding YFP and a floxed PGK-neo cassette. Transient expression of cre recombinase removed the neo cassette. (J:113138)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Th Mutation:  44 strains or lines available
Original:  J:113138 Kelly BB, et al., A tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene. Neuroscience. 2006 Oct 13;142(2):343-54
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory