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Targeted Allele Detail
Symbol: Scn1atm1Wac
Name: sodium channel, voltage-gated, type I, alpha; targeted mutation 1, William A Catterall
MGI ID: MGI:3665322
Synonyms: Nav1.1(-), Scn1a-
Gene: Scn1a  Location: Chr2:66270778-66440840 bp, - strand  Genetic Position: Chr2, 39.13 cM
Germline Transmission:  Earliest citation of germline transmission: J:113149
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance gene replaced the last coding exon. This exon encodes domain IV downstream of the S3 segment and the cytoplasmic tail. Immunoblot failed to detect protein in mutant brain samples. (J:113149)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn1a Mutation:  64 strains or lines available
Original:  J:113149 Yu FH, et al., Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. Nat Neurosci. 2006 Sep;9(9):1142-9
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory