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Wt1tm2.1Vih
Targeted Allele Detail
Nomenclature
Symbol: Wt1tm2.1Vih
Name: Wilms tumor 1 homolog; targeted mutation 2.1, Vicki Huff
MGI ID: MGI:3665321
Synonyms: Wt1delta
Gene: Wt1  Location: Chr2:105126529-105173616 bp, + strand  Genetic Position: Chr2, 55.06 cM, cytoband E
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111787
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele is a derivative of Wt1tm2Vih in which the floxed exons 8 and 9 were deleted by using an oocyte-specific Zp3-cre transgene, resulting in a shortened protein lacking zinc fingers 2 and 3. (J:111787)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wt1 Mutation:  10 strains or lines available
References
Original:  J:111787 Gao F, et al., The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11987-92
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory