About   Help   FAQ
Targeted Allele Detail
Symbol: Ace2tm1Cof
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; targeted mutation 1, Thomas M Coffman
MGI ID: MGI:3665270
Gene: Ace2  Location: ChrX:162922338-162971414 bp, + strand  Genetic Position: ChrX, 76.12 cM, cytoband F5
Germline Transmission:  Earliest citation of germline transmission: J:113108
Parent Cell Line:  MPI-12D (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced an exon containing sequences encoding the zinc-binding motif HEMGH. Northern blot analysis of RNA derived from kidney of mutant mice revealed that no detectable transcript is expressed from this allele. (J:113108)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ace2 Mutation:  31 strains or lines available
Original:  J:113108 Gurley SB, et al., Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. J Clin Invest. 2006 Aug;116(8):2218-25
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.20
The Jackson Laboratory