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Ace2tm1Cof
Targeted Allele Detail
Nomenclature
Symbol: Ace2tm1Cof
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; targeted mutation 1, Thomas M Coffman
MGI ID: MGI:3665270
Gene: Ace2  Location: ChrX:164139342-164188418 bp, + strand  Genetic Position: ChrX, 76.12 cM, cytoband F5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:113108
Parent Cell Line:  MPI-12D (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced an exon containing sequences encoding the zinc-binding motif HEMGH. Northern blot analysis of RNA derived from kidney of mutant mice revealed that no detectable transcript is expressed from this allele. (J:113108)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ace2 Mutation:  14 strains or lines available
References
Original:  J:113108 Gurley SB, et al., Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. J Clin Invest. 2006 Aug;116(8):2218-25
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/15/2020
MGI 6.15
The Jackson Laboratory