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Mkrn1Gt(RRB087)Byg
Gene trapped Allele Detail
Nomenclature
Symbol: Mkrn1Gt(RRB087)Byg
Name: makorin, ring finger protein, 1; gene trap mutation RRB087, BayGenomics
MGI ID: MGI:3665258
Gene: Mkrn1  Location: Chr6:39397804-39420462 bp, - strand  Genetic Position: Chr6, 18.18 cM
Mutation
origin
Mutant Cell Line:  RRB087
Germline Transmission:  Earliest citation of germline transmission: J:111785
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT1Lxf     Vector Type: gene trap
 
Mutation detailsA gene trap vector inserted into intron 3. Gene-trapped transcripts contain a beta-geo fusion sequence, and lack exons 4-8. The encoded proteins lack four of the Makorin family zinc-finger motifs, including the essential RING E3 ubiquitin ligase domain. Histochemical visualization of the expressed fusion protein refined existing data that this gene is widely expressed and very abundant in specific cell types of the central nervous system and testis. (J:111785)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mkrn1 Mutation:  119 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:111785 Gray TA, et al., The putatively functional Mkrn1-p1 pseudogene is neither expressed nor imprinted, nor does it regulate its source gene in trans. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12039-44
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/21/2020
MGI 6.14
The Jackson Laboratory