Etn3^Ppd
Spontaneous Allele Detail

Summary

• Symbol: Etn3^Ppd
• Name: early transposon element insertion site 3; polypodia
• MGI ID: MGI:3665247
• Gene: Etn3 Location: unknown Genetic Position: ChrX, Syntenic
• Alliance: Etn3^Ppd page

Polypodia caudal appendicular skeletal malformations in Ppd/Y and Ppd/? mice.

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: CD-1

Mutation description

Allele Type: Spontaneous Mutation: Transposon insertion Mutation details: A novel type II early transposon (ETnIIbeta) spontaneously inserted 1.6 Kb downstream of the polyadenylation signal of Dusp9 between two repetitive sequences (SINE and LINE elements) at position ChrX: 73645160 (GRCm38/mm10). This insertion does not disrupt Dusp9, Pnck or any other gene or noncoding RNA. RT-PCR and western blot analysis confirmed increased Dusp9 transcript and protein expression, respectively, in mutant ES cells. (J:207896) Inheritance: Dominant

Location and orientation of the transposon insertion in the Etn3^Ppd allele

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Etn3 Mutation: 1 strain or line available

References

• Original: J:112867 Lehoczky JA, et al., Description and genetic mapping of Polypodia: an X-linked dominant mouse mutant with ectopic caudal limbs and other malformations. Mamm Genome. 2006 Sep;17(9):903-13
• All: 2 reference(s)