Rac1^tm1Brak
Targeted Allele Detail

Summary

• Symbol: Rac1^tm1Brak
• Name: Rac family small GTPase 1; targeted mutation 1, Cord Brakebusch
• MGI ID: MGI:3665172
• Synonyms: Rac1flox, Rac1^lox
• Gene: Rac1 Location: Chr5:143491236-143513786 bp, - strand Genetic Position: Chr5, 82.22 cM
• Alliance: Rac1^tm1Brak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112307
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was introduced upstream of exon 3 and a floxed neo-tk selection cassette was introduced downstream. The neo cassette was removed in the ES cells leaving behind a single downstream loxP site. Cre mediated recombination results in removal of exon 3 and the absence of protein expression. (J:112307)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rac1 Mutation: 21 strains or lines available

References

• Original: J:112307 Chrostek A, et al., Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis. Mol Cell Biol. 2006 Sep;26(18):6957-70
• All: 34 reference(s)