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Targeted Allele Detail
Symbol: Tlr5tm1Flv
Name: toll-like receptor 5; targeted mutation 1, Richard Flavell
MGI ID: MGI:3665162
Gene: Tlr5  Location: Chr1:182954788-182976044 bp, + strand  Genetic Position: Chr1, 86.12 cM
Germline Transmission:  Earliest citation of germline transmission: J:111778
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP-flanked neomycin selection cassette replaced the coding exon for the gene. mRNA expression in mutant and WT BM-derived macrophages was assessed by RT-PCR. Transcripts were absent in mutant but not in WT macrophages. (J:111778)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tlr5 Mutation:  43 strains or lines available
Original:  J:111778 Feuillet V, et al., Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12487-12492
All:  41 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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